Topical Drug Delivery Therapeutics, Drug Absorption and Penetration Enhancement Techniques

The delivery of medications through the skin has long been a fascinating as well difficult subject study. For different medications, topical drug administration brought substantial benefits over systemic route, one most important which is reduced toxicity due to minimal or no exposure non-target organs. Because its simplicity and affordability, preferred method for delivering medicinal substances locally. Topical system includes solid powders, semisolids, liquid preparations, sprays, among other pharmaceutical dose forms. Gels, creams, ointments are often used semisolid preparations medication delivery. methods allow medicine enter circulation at controlled rate by penetrating epidermal layer. New drugs being developed utilizing transdermal approach in addition existing formulations inherent via this route. Although low permeability limits applicability, it does provide non-invasive route administration. Innovative research using penetration-enhancing technologies such iontophoresis, electroporation, microneedles, sonophoresis, others offers promise successful implementation these clinical practice consumer-friendly, dosage This paper examines some promising new strategies enhancing permeability, providing scientific update on recent improvements system. current study focuses modern techniques administering local treatment skin. data can be foundation further development methodologies technologies.
 Keywords: delivery, Recent techniques, TDDS, Advances